Regulation

• Developmental changes in P450 expression  (Compiled by Andrey L. Sukhodub) http://www.icgeb.trieste.it/~p450srv/P450_ageing.html

• List of inducers of P450 enzymes http://medicine.iupui.edu/flockhart/

   

 Structure

• X-ray structures, coordinates and models

  • http://metallo.scripps.edu/PROMISE/P450.html  

  • http://p450terp.swmed.edu/index.htm    (Bill Peterson)

• Models

  • Structural models of P450s http://ws05.pc.chemie.tu-darmstadt.de/research/vrml/index.html (you must download “Cosmo Player” http://www.cai.com/cosmo/ to use this site)

  • Families of structural domains of P450-containing systems (Kirill N. Degtyarenko) http://www.icgeb.trieste.it/~p450srv/P450domains.html

  • Schematic representation of P450 systems domain structure (Kirill N. Degtyarenko) http://www.icgeb.trieste.it/~p450srv/domstr.html

• Sequence similarities among P450s

  • Protein sequence alignments for P450 (David Nelson) http://drnelson.utmem.edu/Alignments.html

Function

• Mechanism

  • NADPH-Cytochrome P450 Reductase (Todd Porter) http://www.uky.edu/Pharmacy/ps/porter/CPR.htm

• Xenobiotic metabolism

  • Could include lists of compounds that are metabolized by specific P450 enzymes

• Metabolism of endogenous compounds

  • To include endogenous compounds and the P450 enzymes responsible for their formation/degradation (e.g. bile acids, arachidonic acid metabolites, EETs and Hetes, steroids, cholesterol, etc.).

• Enzyme-substrate selectivity

  • Steroid ligands of P450s http://www.icgeb.trieste.it/~p450srv/steroid_list.html

  • List of substrates for human P450 enzymes (David Flockhart) http://medicine.iupui.edu/flockhart/

  • Clinically used drugs metabolized by Cytochrome P450 http://medicine.iupui.edu/flockhart/
    List of common inhibitors for human P450 enzymes http://medicine.iupui.edu/flockhart

     

Genomics

• Gene Sequence

  • P450 gene databases (David Nelson) http://drnelson.utmem.edu/Databases.html

  • Arabidopsis and Drosophila P450 pages http://ag.arizona.edu/p450/

  • Gene Sequence Directory of P450s (Kirill N. Degtyarenko) http://www.icgeb.trieste.it/~p450srv/new/

• Polymorphisms

  • Human Cytochrome P450 (CYP) Allele Nomenclature Committee http://www.imm.ki.se/CYPalleles/

  • Chromosomal Locations and Common Polymorphisms in Human P450 genes http://medicine.iupui.edu/flockhart