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2008 Graduate Student Best Abstract Awards:

First Place: Steven Hart, University of Kansas Medical Center. Advisor: Xiaobo Zhong. “Single nucleotide polymorphisms in cytochrome P450 oxidoreductase influence drug metabolism”

Second Place: Shuxin Han, Northeastern Ohio Universities College of Medicine and Pharmacy. Advisor: John Chiang. “Vitamin D receptor is expressed in human livers and inhibits CYP7A1 gene transcription”

 

2008 Postdoctoral Scientist Awards:

First Place: Chunshan Gui, University of Kansas Medical Center. Advisor: Bruno Hagenbuch. “Molecular determinants for substrate selectivity of OATP1B3”

Second Place: Ye Li, University of Kansas Medical Center. Advisor: Xiaobo Zhong. “Genetic polymorphisms in the RNA polymerase II core promoter and enhancer elements of the UGT1A1 promoter influence activation of its gene transcription”

 

James R. Gillette Drug Metabolism Best Papers of 2007

Metabolism category:

Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O and Tukey TH. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 35:419-427, 2007.

 

Pharmacokinetics/Transporters category:

Shen H, Ocheltree SM, Hu Y, Keep RF and Smith DE. Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice. Drug Metab Dispos 35:1209-1216, 2007.

EB2008 pictures 6

 

     Pictures from EB2008

2006 Graduate Student Best Abstract Awards:

  • First Place: Jessica Bonzo, University of California San Diego. Advisor:
    Robert Tukey  "Transgenic UDP-glucuronosyltransferase 1 mice are protected from obesity-induced type 2 diabetes."

  • Second Place: Dinesh Puppala, University of Kentucky. Advisor: Hollie Swanson "Inhibition of the aryl hydrocarbon receptor signaling pathway and cigarette smoke induced cell transformation by select dietary flavonoids."


2006 Postdoctoral Scientist Awards:

  • First Place: Yonghong Zhao, University of Texas Medical Branch. Advisor:
    Jim Halpert  "Conformational plasticity of cytochrome P450 2B4: crystallographic and solution studies."

  • Second Place: Xia Wen, Medical University of South Carolina. Advisor: Thomas Walle  "Methylation protects dietary flavonoids from rapid hepatic metabolism."

 

2006 Election Results:

  • Chair-Elect: Kenneth Thummel, University of Washington, Seattle

  • Secretary/Treasurer-Elect: John Chiang, Northeastern Ohio University College of Medicine

Terms begin July 1, 2006

Pictures from EB2006:

Click HERE to see them

 

James R. Gillette Drug Metabolism Best Papers of 2005

Metabolism category:

Bu H-Z, Kang P, Zhao P, Pool WF, Wu EY. A simple sequential incubation method for deconvoluting the complicated sequential metabolism of capravirine in humans. Drug Metab Dispos 33(10): 1438-1445, 2005.

 

Pharmacokinetics/Transporters category:

Bourasset F, Bernard K, Munoz C, Genissel P, Scherrmann J-M.  Neuropharmacokinetics of a new a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2-4-benzothiadiazine- 1,1-dioxide], in the rat. Drug Metab Dispos 33(8): 1137-1143, 2005.

 

Pictures from EB2005

Click to enlarge!

2005 Winners of Best Poster Competition

Graduate Student Division 

  • First Place: Mohamed A Abdelmegeed, Wayne State Univ.  Acetoacetate Inhibits Cytochrome P450 (CYP) 2E1 mRNA Through Suppression of Transcription and Induces CYP2E1 Protein Through Increased Translation and Decreased Protein Degradation in Primary Cultured Rat Hepatocytes. Advisor: Raymond F Novak 1

  • Second Place:  Xu Yang Univ of Washington Identification of 1α, 25-dihydroxyvitamin D3 as a novel endogenous substrate for cytochrome P450 3A4.  Advisor:  Kenneth E. Thummel 2

 

Postdoctoral Division 

  • First Place:  Xiuling Zhang, New York State Dept of Health Variable Expression of CYP2A6 and CYP2A13 Proteins In Human Lung and Nasal Mucosa.  Advosor:   Xinxin Ding

  • Second Place:  Sanjoy Roychowdhury Univ of Iowa Visualization and quantification of intracellular protein adducts in human epidermal keratinocytes exposed to sulfamethoxazole (SMX) and dapsone (DDS). Advisor:  Craig K. Svensson

 

2004 Election results:

  • Chair-Elect: David S. Riddick, University of Toronto

  • Secretary/Treasurer-Elect: Xinxin Ding, Wadsworth Center, NYSDOH

 Terms begin July 1, 2004
 

2004 Graduate Student and Post-Doctoral Awards

The ASPET Division for Drug Metabolism presented its Graduate Student and Post-Doctoral Best Paper Awards at the Experimental Biology 2004 meeting in Washington, DC, April 17-21, 2004. The award winners were as follows:

Graduate Student Category

  • First prize: Yen Weng, Department of Environmental Health and Toxicology, Wadsworth Center, School of Public Health, SUNY at Albany (Supervisor: Xinxin Ding), for the poster entitled “Microarray analysis of hepatic gene expression in liver-specific NADPH-cytochrome P450 reductase (Cpr)-knockout and global Cpr-knockdown mouse models.”
     

  • Second prize: Tiangan Li, Department of Biochemistry and Molecular Pathology, Northern Ohio Universities College of Medicine (supervisor: John Chiang), for the poster entitled “Lithocholic acid (LCA) inhibits human cholesterol 7-hydroxylase transcription via pregnane X receptor (PXR)-mediated pathway.”


Post-Doctoral Category

  • First prize: Badanthadka Murali, Department of Toxicology, University of Louisiana at Monroe (Supervisor: Harihara Mehendale), for the poster entitled “Resistance of F344 rats to chlordecone-potentiated CCl4 hepatotoxicity and lethality is age-dependent.”
     

  • Second prize: Cheng Fang, Wadsworth Center, New York State Department of Health (Supervisor: Xinxin Ding), for the poster entitled “Preparation and initial characterization of a transgenic mouse model with forebrain-specific knockout of the NADPH-cytochrome P450 reductase (Cpr) gene.”

EB 2003 Activities

Graduate Student and Post-Doctoral Awards

The ASPET Division for Drug Metabolism presented its Graduate Student and Post-Doctoral Best Paper Awards at the Experimental Biology 2003 meeting in San Diego, April 11-15, 2003.  The award winners were as follows:

Graduate Student category

  • First prize:  Yannick Duguay, Université Laval (Supervisor: Chantal Guillemette), for the         poster entitled “UGT2B7: novel genomic variants in the promoter and functional consequences”.

  • Second prize:  Asmeen Jahan, Northeastern Ohio Universities College of Medicine (Supervisor: John Chiang), for the poster entitled “Suppression of the human sterol 12a-hydroxylase (CYP8B1) gene by interleukin-1ß”.

Post-Doctoral category

  • First prize:  Emily Scott, University of Texas Medical Branch (Supervisor: James Halpert), for the oral presentation entitled “Crystallization of a mammalian cytochrome P450 from the 2B subfamily”.

  • Second prize:  Santosh Kumar, University of Texas Medical Branch (Supervisor: James Halpert), for the oral presentation entitled “Engineering of cytochrome P450 2B1 for progesterone 21-hydroxylase activity”.

2003 Election results:

  • Chair-Elect: Timothy S. Tracy, University of Minnesota

  • Craig K. Svensson, University of Iowa