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Division for Toxicology Symposia at EB2010 Anaheim, April 24-28
(printable version is
HERE
Symposium 1:
Regulating the Regulators: Redox regulation and stress response
proteins
Co-Sponsor:
Division for Drug Metabolism
Chair:
Daret St. Clair
Cellular redox status
(oxidizing/reducing conditions) is known to play several
important roles in signaling of life and death processes.
Transcription regulators are important targets of redox
regulation that carry out the survival and death responses.
However, increasing evidence suggests that cellular redox status
is also regulated by the activity of transcription factors and
modifiers such as NF-kB, p53 and SIRT.
Hence, activation of these proteins and the subsequent
alteration of cellular redox status are interrelated. In light
of these new findings, we believed that a topic on the
connections between cellular redox status and redox sensitive
proteins is timely and should be of importance to many
scientists attending ASPET meetings. Given that cellular redox
status contributes to almost all aspects of biological function,
and transcription regulatory proteins are critical for normal
cellular functions, this proposed session will serve as an
excellent platform to bring together two important fields: redox
and transcription regulation.
Introduction
to the connections between cellular redox status and
transcription responses
Daret St.
Clair, PhD,
Department of Toxicology,
University
of Kentucky
p53 regulates
mitochondrial function
Paul M.
Hwang, MD, PhD, Cardiology Branch, National Heart, Lung, and
Blood Institute, NIH
ROS and
p53 modulators in cancer specific apoptosis
Sam Lee, PhD,
Cutaneous Biology Research Laboratory, Harvard Medical School
SIRT3 is a
mitochondrial tumor suppressor gene required for maintenance of
mitochondrial integrity and oxidative metabolism during stress
David
Gius, MD, PhD, Radiation Oncology Branch, NIH
Mitochondria: novel
regulators of the Keap1/Nrf-2antioxidant pathway
Aimee Landar, PhD,
Center for Free Radical Biology, University of
Alabama-Birmingham
(Young Investigator
Speaker)
The bi-directional
role of p53 on MnSOD expression
Sanjit
Dhar, PhD, Graduate Center for Toxicology, University of
Kentucky
(Young Investigator
Speaker)
Symposium 2: Role of mitochondria in pathogenesis of drug
hepatotoxicity
Co-Sponsor:
Division for Drug Metabolism & Division for Integrative Systems,
Translational and Clinical Pharmacology
Chair:
Neil Kaplowitz
Mitocondria have attracted renewed
interest because of their role in oxidative stress and as
potential target to toxic drugs. Drugs that interfere with
electron transport promote ROS production. Critical in handling
this oxidative stress is the status of the mitochondrial defense
and its compartmentation. The eventual exhaustion of this
defense exposes the cytoplasm to ROS. The effect on sustained
activation of signal transduction pathways may then lead to JNK
targeting to mitochondria and cell death. The discussion of this
area of research will bring attention to the importance of
mitochondria as a primary and secondary target of hepatotoxic
drugs. This will stimulate discussion and more work to advance
the field of hepatotoxicity.
Introduction
Neil Kaplowitz, MD, Division of Gastroenterology and Liver
Diseases,
University
of Southern California
Compartmentation of
oxidative stress defense in mitochondria: implications for drug
toxicity
This talk will address the
role of mitochondrial thioredoxin and GSH and its relation to
other compartments
Dean Jones, PhD, Division of Ophthalmology,
Emory
University School of Medicine
Mitochondrial permeability
transition
This talk will focus on
the MPT, what regulates it and its contribution
John LeMasters, MD, PhD, Department of Biochemistry and
Molecular Biology and Pharmaceutical Sciences
Medical University of Southern Carolina
Interplay of signal
transduction and mitochondria in the acetaminophen model
This talk will address
role of kinases (JNK, etc) in mediating oxidative stress induced
necrosis
Derick Han, PhD, Division of Gastrointestinal and Liver
Diseases,
University
of Southern California
(Young Investigator Speaker)
Threshold for
mitochondrial participation in idiosyncratic DILI
This talk will address the
SOD+/- in increasing or unmasking of drugs and mechanisms
Urs Boelsterli, PhD, Department of Pharmaceutical Sciences,
University of Connecticut School of Pharmacy
Symposium 3: Div Tox-sponsored symposium: ABC transporters,
their role in physiology, toxicology and cancer
Chair: John Schuetz
Details are being
finalized |
Please
strongly encourage your graduate students and postdocs
to submit abstracts and apply for the PostDoc and
Graduate Student Best Abstract Awards for EB2010.
The links for the Award applications are below. Be sure
to select the Toxicology Division.